Relaxin Signals through a RXFP1-pERK-nNOS-NO-cGMP-Dependent Pathway to Up-Regulate Matrix Metalloproteinases: The Additional Involvement of iNOS

The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide Receptor 1 (RXFP1), extracellular signal-regulated kinase (ERK)1/2 phosphorylation (pERK) and a neuronal nitric oxide (N...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chow, Bryna Suet Man, Chew, Elaine Guo Yan, Zhao, Chongxin, Bathgate, Ross A. D., Hewitson, Tim D., Samuel, Chrishan S.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425563/
https://ncbi.nlm.nih.gov/pubmed/22936987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042714
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