Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Human gene-2 (H2) relaxin is currently in Phase III clinical trials for the treatment of acute heart failure. It is a 53-amino acid insulin-like peptide comprising two chains and three disulfide bonds. It interacts with two of the relaxin family peptide (RXFP) receptors. Although its cognate recepto...

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Detalhes bibliográficos
Principais autores: Chan, Linda J., Rosengren, K. Johan, Layfield, Sharon L., Bathgate, Ross A. D., Separovic, Frances, Samuel, Chrishan S., Hossain, Mohammed A., Wade, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3510815/
https://ncbi.nlm.nih.gov/pubmed/23024363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.409284
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