Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3

The neuropeptide relaxin-3 and its receptor relaxin family peptide receptor-3 (RXFP3) play key roles in modulating behavior such as memory and learning, food intake, and reward seeking. A linear relaxin-3 antagonist (R3 B1-22R) based on a modified and truncated relaxin-3 B-chain was recently develop...

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Vydáno v:J Biol Chem
Hlavní autoři: Haugaard-Kedström, Linda M., Lee, Han Siean, Jones, Maryon V., Song, Angela, Rathod, Vishaal, Hossain, Mohammed Akhter, Bathgate, Ross A. D., Rosengren, K. Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187623/
https://ncbi.nlm.nih.gov/pubmed/30131342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002611
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