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Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in mice

BACKGROUND AND PURPOSE: Inflammasomes are multimeric complexes that facilitate caspase‐1‐mediated processing of the pro‐inflammatory cytokines IL‐1β and IL‐18. Clinical hypertension is associated with renal inflammation and elevated circulating levels of IL‐1β and IL‐18. Therefore, we investigated w...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Krishnan, S M, Dowling, J K, Ling, Y H, Diep, H, Chan, C T, Ferens, D, Kett, M M, Pinar, A, Samuel, C S, Vinh, A, Arumugam, T V, Hewitson, T D, Kemp‐Harper, B K, Robertson, A A B, Cooper, M A, Latz, E, Mansell, A, Sobey, C G, Drummond, G R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742291/
https://ncbi.nlm.nih.gov/pubmed/26103560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13230
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