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A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnology reagents as well as a new class of therapeutic can...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Paul, Ananya, Guo, Pu, Boykin, David W., Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6429135/
https://ncbi.nlm.nih.gov/pubmed/30866557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24050946
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