Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncoproteins ind...

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Foilsithe in:mBio
Main Authors: Starrett, Gabriel J., Serebrenik, Artur A., Roelofs, Pieter A., McCann, Jennifer L., Verhalen, Brandy, Jarvis, Matthew C., Stewart, Teneale A., Law, Emily K., Krupp, Annabel, Jiang, Mengxi, Martens, John W. M., Cahir-McFarland, Ellen, Span, Paul N., Harris, Reuben S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2019
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428753/
https://ncbi.nlm.nih.gov/pubmed/30723127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02690-18
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