Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncoproteins ind...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:mBio
Autors principals: Starrett, Gabriel J., Serebrenik, Artur A., Roelofs, Pieter A., McCann, Jennifer L., Verhalen, Brandy, Jarvis, Matthew C., Stewart, Teneale A., Law, Emily K., Krupp, Annabel, Jiang, Mengxi, Martens, John W. M., Cahir-McFarland, Ellen, Span, Paul N., Harris, Reuben S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428753/
https://ncbi.nlm.nih.gov/pubmed/30723127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02690-18
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars