Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncoproteins ind...

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Pubblicato in:mBio
Autori principali: Starrett, Gabriel J., Serebrenik, Artur A., Roelofs, Pieter A., McCann, Jennifer L., Verhalen, Brandy, Jarvis, Matthew C., Stewart, Teneale A., Law, Emily K., Krupp, Annabel, Jiang, Mengxi, Martens, John W. M., Cahir-McFarland, Ellen, Span, Paul N., Harris, Reuben S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428753/
https://ncbi.nlm.nih.gov/pubmed/30723127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02690-18
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