Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism

APOBEC3B is a single-stranded DNA cytosine deaminase with beneficial innate antiviral functions. However, misregulated APOBEC3B can also be detrimental by inflicting APOBEC signature C-to-T and C-to-G mutations in genomic DNA of multiple cancer types. Polyomavirus and papillomavirus oncoproteins ind...

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Publicado no:mBio
Main Authors: Starrett, Gabriel J., Serebrenik, Artur A., Roelofs, Pieter A., McCann, Jennifer L., Verhalen, Brandy, Jarvis, Matthew C., Stewart, Teneale A., Law, Emily K., Krupp, Annabel, Jiang, Mengxi, Martens, John W. M., Cahir-McFarland, Ellen, Span, Paul N., Harris, Reuben S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428753/
https://ncbi.nlm.nih.gov/pubmed/30723127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02690-18
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