Reversible histone glycation is associated with disease-related changes in chromatin architecture

Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that accumulate under normal physiological conditions and are stimulated by changes in the cellular microenvironment. Glycation, the hallmark of diabetes, is a prevalent NECM associated with an array of pathologies....

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zheng, Qingfei, Omans, Nathaniel D., Leicher, Rachel, Osunsade, Adewola, Agustinus, Albert S., Finkin-Groner, Efrat, D’Ambrosio, Hannah, Liu, Bo, Chandarlapaty, Sarat, Liu, Shixin, David, Yael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6426841/
https://ncbi.nlm.nih.gov/pubmed/30894531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09192-z
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