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Synthesis of an Alkynyl Methylglyoxal Probe to Investigate Nonenzymatic Histone Glycation
Methylglyoxal (MGO) is a reactive dicarbonyl metabolite that modifies histones in vivo and induces changes in chromatin structure and function. Here we report the synthesis and application of a chemical probe for investigating MGO-glycation. A two-step synthesis of a Cu-click compatible alkynyl oxoa...
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| Publicado no: | J Org Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8018604/ https://ncbi.nlm.nih.gov/pubmed/31875401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.9b02504 |
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