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Controlling the viscosities of antibody solutions through control of their binding sites

For biotechnological drugs, it is desirable to formulate antibody solutions with low viscosities. We go beyond previous colloid theories in treating protein–protein self–association of molecules that are antibody–shaped and flexible and have spatially specific binding sites. We consider interactions...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Mol Liq
Hauptverfasser: Kastelic, Miha, Dill, Ken A., Kalyuzhnyi, Yura V., Vlachy, Vojko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6425977/
https://ncbi.nlm.nih.gov/pubmed/30906093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molliq.2017.11.106
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