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Protein aggregation in salt solutions

Protein aggregation is broadly important in diseases and in formulations of biological drugs. Here, we develop a theoretical model for reversible protein–protein aggregation in salt solutions. We treat proteins as hard spheres having square-well-energy binding sites, using Wertheim’s thermodynamic p...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kastelic, Miha, Kalyuzhnyi, Yurij V., Hribar-Lee, Barbara, Dill, Ken A., Vlachy, Vojko
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4450416/
https://ncbi.nlm.nih.gov/pubmed/25964322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507303112
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