The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenylation in OA synovial samples was investigated, and the potenti...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Ashraf, Sadaf, Radhi, Masar, Gowler, Peter, Burston, James J., Gandhi, Raj D., Thorn, Graeme J., Piccinini, Anna M., Walsh, David A., Chapman, Victoria, de Moor, Cornelia H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423048/
https://ncbi.nlm.nih.gov/pubmed/30886197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-41140-1
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