Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis

OBJECTIVES: Nerve growth factor (NGF) is a promising analgesic target, particularly in osteoarthritis (OA) where existing therapies are inadequate. We hypothesised that pain responses to NGF are increased in OA joints. Here, NGF-evoked pain behaviour was compared in two rodent models of OA, and poss...

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Détails bibliographiques
Auteurs principaux: Ashraf, Sadaf, Mapp, Paul Ian, Burston, James, Bennett, Andrew John, Chapman, Victoria, Walsh, David Andrew
Format: Artigo
Langue:Inglês
Publié: BMJ Publishing Group 2014
Sujets:
Basic and Translational Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145450/
https://ncbi.nlm.nih.gov/pubmed/23852764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203416
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