Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis

BACKGROUND: Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). OBJECTIVES: To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. METHODS: Male Sprague Dawley...

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Detalhes bibliográficos
Main Authors: Sagar, Devi Rani, Ashraf, Sadaf, Xu, Luting, Burston, James J, Menhinick, Matthew R, Poulter, Caroline L, Bennett, Andrew J, Walsh, David A, Chapman, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112443/
https://ncbi.nlm.nih.gov/pubmed/23723320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203260
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