Refining surgical models of osteoarthritis in mice and rats alters pain phenotype but not joint pathology

The relationship between osteoarthritis (OA) structural change and pain is complex. Surgical models of OA in rodents are often rapid in onset, limiting mechanistic utility and translational validity. We aimed to investigate the effect of refining surgical small rodent models of OA on both joint path...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gowler, Peter R. W., Mapp, Paul I., Burston, James J., Shahtaheri, Mohsen, Walsh, David A., Chapman, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523978/
https://ncbi.nlm.nih.gov/pubmed/32991618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239663
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