Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties

Chromosomal duplication is targeted by various chemotherapeutic agents for the treatment of cancer. However, there is no specific inhibitor of DNA polymerases that is viable for cancer management. Through structure-based in silico screening of the ZINC database, we identified a specific inhibitor of...

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Detalles Bibliográficos
Publicado en:Cancer Biol Ther
Main Authors: Mishra, Bhanvi, Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbigniew, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422523/
https://ncbi.nlm.nih.gov/pubmed/30427259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1529126
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