Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties

Chromosomal duplication is targeted by various chemotherapeutic agents for the treatment of cancer. However, there is no specific inhibitor of DNA polymerases that is viable for cancer management. Through structure-based in silico screening of the ZINC database, we identified a specific inhibitor of...

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Vydáno v:Cancer Biol Ther
Hlavní autoři: Mishra, Bhanvi, Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbigniew, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422523/
https://ncbi.nlm.nih.gov/pubmed/30427259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1529126
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