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Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties

Chromosomal duplication is targeted by various chemotherapeutic agents for the treatment of cancer. However, there is no specific inhibitor of DNA polymerases that is viable for cancer management. Through structure-based in silico screening of the ZINC database, we identified a specific inhibitor of...

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Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Mishra, Bhanvi, Zhang, Sufang, Zhao, Hong, Darzynkiewicz, Zbigniew, Lee, Ernest Y.C., Lee, Marietta Y.W.T., Zhang, Zhongtao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6422523/
https://ncbi.nlm.nih.gov/pubmed/30427259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2018.1529126
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