The tail that wags the dog: p12, the smallest subunit of DNA polymerase δ, is degraded by ubiquitin ligases in response to DNA damage and during cell cycle progression

DNA polymerase δ (Pol δ) is a key enzyme in eukaryotic DNA replication. Human Pol δ is a heterotetramer whose p12 subunit is degraded in response to DNA damage, leading to the in vivo conversion of Pol δ4 to Pol δ3. Two E3 ubiquitin ligases, RNF8 and CRL4(Cdt2), participate in the DNA damage-induced...

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Detalhes bibliográficos
Main Authors: Lee, Marietta YWT, Zhang, Sufang, Lin, Szu Hua Sharon, Wang, Xiaoxiao, Darzynkiewicz, Zbigniew, Zhang, Zhongtao, Lee, Ernest YC
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Perspective
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3925730/
https://ncbi.nlm.nih.gov/pubmed/24300032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27407
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