A carregar...
Loss of the p12 subunit of DNA Polymerase Delta Leads to a Defect in HR and Sensitization to PARP Inhibitors
Human DNA polymerase δ is normally present in unstressed, non-dividing cells as a heterotetramer (Pol δ4). Its smallest subunit, p12, is transiently degraded in response to UV damage, as well as during the entry into S-phase, resulting in the conversion of Pol δ4 to a trimer (Pol δ3). In order to fu...
Na minha lista:
| Publicado no: | DNA Repair (Amst) |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6312503/ https://ncbi.nlm.nih.gov/pubmed/30470508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.11.003 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|