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Loss of the p12 subunit of DNA Polymerase Delta Leads to a Defect in HR and Sensitization to PARP Inhibitors

Human DNA polymerase δ is normally present in unstressed, non-dividing cells as a heterotetramer (Pol δ4). Its smallest subunit, p12, is transiently degraded in response to UV damage, as well as during the entry into S-phase, resulting in the conversion of Pol δ4 to a trimer (Pol δ3). In order to fu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:DNA Repair (Amst)
Prif Awduron: Zhang, Sufang, Chao, Hsiao Hsiang, Wang, Xiaoxiao, Zhang, Zhongtao, Lee, Ernest Y.C., Lee, Marietta Y.W.T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6312503/
https://ncbi.nlm.nih.gov/pubmed/30470508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.11.003
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