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Loss of the p12 subunit of DNA Polymerase Delta Leads to a Defect in HR and Sensitization to PARP Inhibitors
Human DNA polymerase δ is normally present in unstressed, non-dividing cells as a heterotetramer (Pol δ4). Its smallest subunit, p12, is transiently degraded in response to UV damage, as well as during the entry into S-phase, resulting in the conversion of Pol δ4 to a trimer (Pol δ3). In order to fu...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | DNA Repair (Amst) |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6312503/ https://ncbi.nlm.nih.gov/pubmed/30470508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2018.11.003 |
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