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Role of Aldose Reductase in Diabetes-Induced Retinal Microglia Activation

Diabetes-induced hyperglycemia plays a key pathogenic role in degenerative retinal diseases. In diabetic hyperglycemia, aldose reductase (AR) is elevated and linked to the pathogenesis of diabetic retinopathy (DR) and cataract. Retinal microglia (RMG), the resident immune cells in the retina, are th...

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Bibliographic Details
Published in:Chem Biol Interact
Main Authors: Chang, Kun-Che, Shieh, Biehuoy, Petrash, J. Mark
Format: Artigo
Language:Inglês
Published: 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421082/
https://ncbi.nlm.nih.gov/pubmed/30682331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2019.01.020
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