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Diabetes-Independent Retinal Phenotypes in an Aldose Reductase Transgenic Mouse Model

Aldose reductase (AR), the first and rate-limiting enzyme of the polyol pathway, has been implicated in the onset and development of the ocular complications of diabetes, including cataracts and retinopathy. Despite decades of research conducted to address possible mechanisms, questions still persis...

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Bibliographic Details
Published in:Metabolites
Main Authors: Petrash, Jonathan Mark, Shieh, Biehuoy, Ammar, David A., Pedler, Michelle G., Orlicky, David J.
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8305400/
https://ncbi.nlm.nih.gov/pubmed/34357344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11070450
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