Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors

We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative analysis of the X-ray crystallographic struct...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Choi, Jun Yong, Fuerst, Rita, Knapinska, Anna M., Taylor, Alexander B., Smith, Lyndsay, Cao, Xiaohang, Hart, P. John, Fields, Gregg B., Roush, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420151/
https://ncbi.nlm.nih.gov/pubmed/28653849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00514
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