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Development of matrix metalloproteinase-13 inhibitors – A structure-activity/structure-property relationship study
A structure-activity/structure-property relationship study based on the physicochemical as well as in vitro pharmacokinetic properties of a first generation matrix metalloproteinase (MMP)-13 inhibitor (2) was undertaken. After systematic variation of inhibitor 2, compound 31 was identified which exh...
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| Publié dans: | Bioorg Med Chem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6379921/ https://ncbi.nlm.nih.gov/pubmed/30249495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.08.020 |
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