Development of matrix metalloproteinase-13 inhibitors – A structure-activity/structure-property relationship study

A structure-activity/structure-property relationship study based on the physicochemical as well as in vitro pharmacokinetic properties of a first generation matrix metalloproteinase (MMP)-13 inhibitor (2) was undertaken. After systematic variation of inhibitor 2, compound 31 was identified which exh...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Fuerst, Rita, Choi, Jun Yong, Knapinska, Anna M., Smith, Lyndsay, Cameron, Michael D., Ruiz, Claudia, Fields, Gregg B., Roush, William R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379921/
https://ncbi.nlm.nih.gov/pubmed/30249495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2018.08.020
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