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Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1

Existing treatments against drug addiction are often ineffective due to the complexity of the networks of protein-drug and protein-protein interactions (PPIs) that mediate the development of drug addiction and related neurobiological disorders. There is an urgent need for understanding the molecular...

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Pubblicato in:Front Pharmacol
Autori principali: Pei, Fen, Li, Hongchun, Liu, Bing, Bahar, Ivet
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418047/
https://ncbi.nlm.nih.gov/pubmed/30906261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00191
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