Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates natural killer (NK) cell development and function, but the exact underlying mechanisms remain unclear. Here, we show, via conditional deletion of Raptor (mTORC1) or Rictor (mTORC2), that mTORC1 and mTORC2 prom...

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Pubblicato in:Nat Commun
Autori principali: Wang, Fangjie, Meng, Meng, Mo, Banghui, Yang, Yao, Ji, Yan, Huang, Pei, Lai, Wenjing, Pan, Xiaodong, You, Tingting, Luo, Hongqin, Guan, Xiao, Deng, Yafei, Yuan, Shunzong, Chu, Jianhong, Namaka, Michael, Hughes, Tiffany, Ye, Lilin, Yu, Jianhua, Li, Xiaohui, Deng, Youcai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242843/
https://ncbi.nlm.nih.gov/pubmed/30451838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07277-9
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