Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals

Mucosal-associated invariant T (MAIT) cells have important functions in immune responses against pathogens and in diseases, but mechanisms controlling MAIT cell development and effector lineage differentiation remain unclear. Here, we report that IL-2/IL-15 receptor β chain and inducible costimulato...

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Vydáno v:Nat Commun
Hlavní autoři: Tao, Huishan, Pan, Yun, Chu, Shuai, Li, Lei, Xie, Jinhai, Wang, Peng, Zhang, Shimeng, Reddy, Srija, Sleasman, John W., Zhong, Xiao-Ping
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8016978/
https://ncbi.nlm.nih.gov/pubmed/33795689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22162-8
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