Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission

Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in neurons it regulates synaptic transmission, which is thought to be a major mechanism through which altered mTOR signaling leads to neurological disease. Although previous studies have delineated postsynaptic r...

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Veröffentlicht in:eLife
Hauptverfasser: McCabe, Matthew P, Cullen, Erin R, Barrows, Caitlynn M, Shore, Amy N, Tooke, Katherine I, Laprade, Kathryn A, Stafford, James M, Weston, Matthew C
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080408/
https://ncbi.nlm.nih.gov/pubmed/32125271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51440
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