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CRISPR-Cas9 circular permutants as programmable scaffolds for genome modification
The ability to engineer natural proteins is pivotal to a future, pragmatic biology. CRISPR proteins have revolutionized genome modification, yet the CRISPR-Cas9 scaffold is not ideal for fusions or activation by cellular triggers. Here we show that topological rearrangement of Cas9 using circular pe...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6414052/ https://ncbi.nlm.nih.gov/pubmed/30633905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.052 |
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