A carregar...
R-loop formation by dCas9 is mutagenic in Saccharomyces cerevisiae
Cas9 binds and cleaves specific DNA sequences by inducing the formation of an R-loop between the guide RNA and its genomic target. While targeting of active Cas9 to a genomic locus is highly mutagenic because Cas9 creates DNA double strand breaks, targeting of dead Cas9 (dCas9) is presumed not to be...
Na minha lista:
| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6411842/ https://ncbi.nlm.nih.gov/pubmed/30590793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1278 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|