The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response regulates recruitment, activity, and clearance of repair factors. However, our understanding of a role for deSUMOylation in this process is limited. Here we identify different mechanistic roles for deSUMOylatio...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Garvin, Alexander J., Walker, Alexandra K., Densham, Ruth M., Chauhan, Anoop Singh, Stone, Helen R., Mackay, Hannah L., Jamshad, Mohammed, Starowicz, Katarzyna, Daza-Martin, Manuel, Ronson, George E., Lanz, Alexander J., Beesley, James F., Morris, Joanna R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411010/
https://ncbi.nlm.nih.gov/pubmed/30796017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.321125.118
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