The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair

SUMO conjugation is known to occur in response to double-stranded DNA breaks in mammalian cells, but whether SUMO deconjugation has a role remains unclear. Here, we show that the SUMO/Sentrin/Smt3-specific peptidase, SENP7, interacts with the chromatin repressive KRAB-associated protein 1 (KAP1) thr...

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Bibliografiske detaljer
Main Authors: Garvin, Alexander J, Densham, Ruth M, Blair-Reid, Sarah A, Pratt, Kenny M, Stone, Helen R, Weekes, Daniel, Lawrence, Kirsty J, Morris, Joanna R
Format: Artigo
Sprog:Inglês
Udgivet: European Molecular Biology Organization 2013
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818072/
https://ncbi.nlm.nih.gov/pubmed/24018422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.141
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