DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells

Inflammatory bowel disease (IBD) is a complex autoimmune disorder recently shown to be associated with SUMOylation, a post-translational modification mechanism. Here, we have identified a link between epithelial deSUMOylases and inflammation in IBD. DeSUMOylase SENP7 was seen to be upregulated speci...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Suhail, Aamir, Rizvi, Zaigham Abbas, Mujagond, Prabhakar, Ali, Syed Azmal, Gaur, Preksha, Singh, Mukesh, Ahuja, Vineet, Awasthi, Amit, Srikanth, Chittur Venkateshwaran
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617169/
https://ncbi.nlm.nih.gov/pubmed/31825833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.028
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