A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency

A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during latency. Mutation and inhibitor studies reveal that LUNA en...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Poole, Emma L., Kew, Verity G., Lau, Jonathan C.H., Murray, Matthew J., Stamminger, Thomas, Sinclair, John H., Reeves, Matthew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077246/
https://ncbi.nlm.nih.gov/pubmed/30021158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.048
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