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A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during latency. Mutation and inhibitor studies reveal that LUNA en...
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| Izdano u: | Cell Rep |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Cell Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6077246/ https://ncbi.nlm.nih.gov/pubmed/30021158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.048 |
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