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MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival
Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6410784/ https://ncbi.nlm.nih.gov/pubmed/30709910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817494116 |
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