Development of siRNA payloads to target KRAS-mutant cancer

RNA interference (RNAi) is a powerful tool for target identification and can lead to novel therapies for pharmacologically intractable targets such as KRAS. RNAi therapy must combine potent siRNA payloads with reliable in vivo delivery for efficient target inhibition. We employed a functional “Senso...

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Bibliografiske detaljer
Main Authors: Yuan, Tina L., Fellmann, Christof, Lee, Chih-Shia, Ritchie, Cayde D., Thapar, Vishal, Lee, Liam C., Hsu, Dennis J., Grace, Danielle, Carver, Joseph O., Zuber, Johannes, Luo, Ji, McCormick, Frank, Lowe, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184972/
https://ncbi.nlm.nih.gov/pubmed/25100204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0900
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