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MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Lee, Chih-Shia, Lee, Liam C., Yuan, Tina L., Chakka, Sirisha, Fellmann, Christof, Lowe, Scott W., Caplen, Natasha J., McCormick, Frank, Luo, Ji
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410784/
https://ncbi.nlm.nih.gov/pubmed/30709910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817494116
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