MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Lee, Chih-Shia, Lee, Liam C., Yuan, Tina L., Chakka, Sirisha, Fellmann, Christof, Lowe, Scott W., Caplen, Natasha J., McCormick, Frank, Luo, Ji
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410784/
https://ncbi.nlm.nih.gov/pubmed/30709910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817494116
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