Development of siRNA payloads to target KRAS-mutant cancer

RNA interference (RNAi) is a powerful tool for target identification and can lead to novel therapies for pharmacologically intractable targets such as KRAS. RNAi therapy must combine potent siRNA payloads with reliable in vivo delivery for efficient target inhibition. We employed a functional “Senso...

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Bibliographic Details
Main Authors: Yuan, Tina L., Fellmann, Christof, Lee, Chih-Shia, Ritchie, Cayde D., Thapar, Vishal, Lee, Liam C., Hsu, Dennis J., Grace, Danielle, Carver, Joseph O., Zuber, Johannes, Luo, Ji, McCormick, Frank, Lowe, Scott W.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184972/
https://ncbi.nlm.nih.gov/pubmed/25100204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0900
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