Diversifying the structure of zinc finger nucleases for high-precision genome editing

Genome editing for therapeutic applications often requires cleavage within a narrow sequence window. Here, to enable such high-precision targeting with zinc-finger nucleases (ZFNs), we have developed an expanded set of architectures that collectively increase the configurational options available fo...

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Pubblicato in:Nat Commun
Autori principali: Paschon, David E., Lussier, Stephanie, Wangzor, Tenzin, Xia, Danny F., Li, Patrick W., Hinkley, Sarah J., Scarlott, Nicholas A., Lam, Stephen C., Waite, Adam J., Truong, Lynn N., Gandhi, Nimisha, Kadam, Bhakti N., Patil, Deepak P., Shivak, David A., Lee, Gary K., Holmes, Michael C., Zhang, Lei, Miller, Jeffrey C., Rebar, Edward J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408524/
https://ncbi.nlm.nih.gov/pubmed/30850604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08867-x
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