Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma

Programmed cell death-1 (PD-1) is expressed on activated T cells and represents an attractive target for gene-editing of tumor targeted T cells prior to adoptive cell transfer (ACT). We used zinc finger nucleases (ZFNs) directed against the gene encoding human PD-1 (PDCD-1) to gene-edit melanoma tum...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Beane, Joal D, Lee, Gary, Zheng, Zhili, Mendel, Matthew, Abate-Daga, Daniel, Bharathan, Mini, Black, Mary, Gandhi, Nimisha, Yu, Zhiya, Chandran, Smita, Giedlin, Martin, Ando, Dale, Miller, Jeff, Paschon, David, Guschin, Dmitry, Rebar, Edward J, Reik, Andreas, Holmes, Michael C, Gregory, Philip D, Restifo, Nicholas P, Rosenberg, Steven A, Morgan, Richard A, Feldman, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4817870/
https://ncbi.nlm.nih.gov/pubmed/25939491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.71
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