A Novel Chimeric Antigen Receptor Against Prostate Stem Cell Antigen Mediates Tumor Destruction in a Humanized Mouse Model of Pancreatic Cancer

Despite advances in the understanding of its molecular pathophysiology, pancreatic cancer remains largely incurable, highlighting the need for novel therapies. We developed a chimeric antigen receptor (CAR) specific for prostate stem cell antigen (PSCA), a glycoprotein that is overexpressed in pancr...

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Publicado en:Hum Gene Ther
Autores principales: Abate-Daga, Daniel, Lagisetty, Kiran H., Tran, Eric, Zheng, Zhili, Gattinoni, Luca, Yu, Zhiya, Burns, William R., Miermont, Anne M., Teper, Yaroslav, Rudloff, Udo, Restifo, Nicholas P., Feldman, Steven A., Rosenberg, Steven A., Morgan, Richard A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2014
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270113/
https://ncbi.nlm.nih.gov/pubmed/24694017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.209
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