Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)–expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19–CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD1...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kochenderfer, James N., Yu, Zhiya, Frasheri, Dorina, Restifo, Nicholas P., Rosenberg, Steven A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2010
Materias:
Lymphoid Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981541/
https://ncbi.nlm.nih.gov/pubmed/20631379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-265041
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares