Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells

Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)–expressing T cells is a new approach for treating advanced B-cell malignancies. To evaluate anti-CD19–CAR-transduced T cells in a murine model of adoptive T-cell therapy, we developed a CAR that specifically recognized murine CD1...

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Bibliografiske detaljer
Main Authors: Kochenderfer, James N., Yu, Zhiya, Frasheri, Dorina, Restifo, Nicholas P., Rosenberg, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2981541/
https://ncbi.nlm.nih.gov/pubmed/20631379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-265041
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