Pilot trial of adoptive transfer of chimeric antigen receptor transduced T cells targeting EGFRvIII in patients with glioblastoma

A deletion variant of epidermal growth factor receptor (EGFRvIII) is a known driver mutation in a subset of primary and secondary glioblastoma multiforme. Adoptive transfer of genetically modified chimeric-antigen receptor (CAR) lymphocytes has demonstrated efficacy in hematologic malignancies but i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunother
Prif Awduron: Goff, Stephanie L., Morgan, Richard A., Yang, James C., Sherry, Richard M., Robbins, Paul F., Restifo, Nicholas P., Feldman, Steven A., Lu, Yong-Chen, Lu, Lily, Zheng, Zhili, Xi, Liqiang, Epstein, Monica, McIntyre, Lori S., Malekzadeh, Parisa, Raffeld, Mark, Fine, Howard A., Rosenberg, Steven A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691897/
https://ncbi.nlm.nih.gov/pubmed/30882547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0000000000000260
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