A Novel Chimeric Antigen Receptor Against Prostate Stem Cell Antigen Mediates Tumor Destruction in a Humanized Mouse Model of Pancreatic Cancer

Despite advances in the understanding of its molecular pathophysiology, pancreatic cancer remains largely incurable, highlighting the need for novel therapies. We developed a chimeric antigen receptor (CAR) specific for prostate stem cell antigen (PSCA), a glycoprotein that is overexpressed in pancr...

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Udgivet i:Hum Gene Ther
Main Authors: Abate-Daga, Daniel, Lagisetty, Kiran H., Tran, Eric, Zheng, Zhili, Gattinoni, Luca, Yu, Zhiya, Burns, William R., Miermont, Anne M., Teper, Yaroslav, Rudloff, Udo, Restifo, Nicholas P., Feldman, Steven A., Rosenberg, Steven A., Morgan, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4270113/
https://ncbi.nlm.nih.gov/pubmed/24694017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.209
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