A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling in Drosophila

Aberrant activation of the Wnt signal transduction pathway triggers the development of colorectal cancer. The ADP-ribose polymerase Tankyrase (TNKS) mediates proteolysis of Axin—a negative regulator of Wnt signaling—and provides a promising therapeutic target for Wnt-driven diseases. Proteolysis of...

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Publicat a:Genetics
Autors principals: Wang, Zhenghan, Tacchelly-Benites, Ofelia, Noble, Geoffrey P., Johnson, Megan K., Gagné, Jean-Philippe, Poirier, Guy G., Ahmed, Yashi
Format: Artigo
Idioma:Inglês
Publicat: Genetics Society of America 2019
Matèries:
Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404254/
https://ncbi.nlm.nih.gov/pubmed/30593492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301393
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