Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism

Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by abnormal bone development that is mainly due to defective intramembranous bone formation by osteoblasts. Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similarities t...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Matsumoto, Yoshinori, La Rose, Jose, Lim, Melissa, Adissu, Hibret A., Law, Napoleon, Mao, Xiaohong, Cong, Feng, Mera, Paula, Karsenty, Gerard, Goltzman, David, Changoor, Adele, Zhang, Lucia, Stajkowski, Megan, Grynpas, Marc D., Bergmann, Carsten, Rottapel, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490759/
https://ncbi.nlm.nih.gov/pubmed/28581440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92233
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