Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism

Cleidocranial dysplasia (CCD) is an autosomal dominant human disorder characterized by abnormal bone development that is mainly due to defective intramembranous bone formation by osteoblasts. Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similarities t...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Matsumoto, Yoshinori, La Rose, Jose, Lim, Melissa, Adissu, Hibret A., Law, Napoleon, Mao, Xiaohong, Cong, Feng, Mera, Paula, Karsenty, Gerard, Goltzman, David, Changoor, Adele, Zhang, Lucia, Stajkowski, Megan, Grynpas, Marc D., Bergmann, Carsten, Rottapel, Robert
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490759/
https://ncbi.nlm.nih.gov/pubmed/28581440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI92233
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