Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras‐Induced ERK (Extracellular Signal‐Regulated Kinase) Signaling Pathway

BACKGROUND: Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate in membrane‐bound G‐protein signaling, including Ras. We dissected the prenyla...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Am Heart Assoc
Auteurs principaux: Sato, Tetsuya, Arakawa, Mamoru, Tashima, Yasushi, Tsuboi, Eitoshi, Burdon, Grayson, Trojan, Jeffrey, Koyano, Tiffany, Youn, Young‐Nam, Penov, Kiril, Pedroza, Albert J., Shabazzi, Mohammad, Palmon, Itai, Nguyen, Marie Noel, Connolly, Andrew J., Yamaguchi, Atsushi, Fischbein, Michael P.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404178/
https://ncbi.nlm.nih.gov/pubmed/30571378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008543
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