Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras‐Induced ERK (Extracellular Signal‐Regulated Kinase) Signaling Pathway

BACKGROUND: Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate in membrane‐bound G‐protein signaling, including Ras. We dissected the prenyla...

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Dettagli Bibliografici
Pubblicato in:J Am Heart Assoc
Autori principali: Sato, Tetsuya, Arakawa, Mamoru, Tashima, Yasushi, Tsuboi, Eitoshi, Burdon, Grayson, Trojan, Jeffrey, Koyano, Tiffany, Youn, Young‐Nam, Penov, Kiril, Pedroza, Albert J., Shabazzi, Mohammad, Palmon, Itai, Nguyen, Marie Noel, Connolly, Andrew J., Yamaguchi, Atsushi, Fischbein, Michael P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404178/
https://ncbi.nlm.nih.gov/pubmed/30571378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008543
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